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sars cov 2 plpro  (TargetMol)


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    Structured Review

    TargetMol sars cov 2 plpro
    Sars Cov 2 Plpro, supplied by TargetMol, used in various techniques. Bioz Stars score: 92/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/sars+cov+2+plpro/PLpro+inhibitor/pm40473007-32-7-41
    Average 92 stars, based on 2 article reviews
    sars cov 2 plpro - by Bioz Stars, 2026-09
    92/100 stars

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    Related Articles

    Binding Assay:

    Article Title: Targeting SARS-CoV-2 Proteases for COVID-19 Antiviral Development
    Article Snippet: A screening campaign using unbiased ChemDiv library (10,000-compound) and a biased, annotated TargetMol Bioactive library (5,370 compounds) for inhibitors only identified CPI-169 as a new inhibitor for SARS-CoV-2 PLpro ( ) ( ). .. C

    Labeling:

    Article Title: Targeting SARS-CoV-2 Proteases for COVID-19 Antiviral Development
    Article Snippet: A screening campaign using unbiased ChemDiv library (10,000-compound) and a biased, annotated TargetMol Bioactive library (5,370 compounds) for inhibitors only identified CPI-169 as a new inhibitor for SARS-CoV-2 PLpro ( ) ( ). .. C



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    Image Search Results


    Docking simulation of GRL-0048 ( 2 ) (orange) or KTS146 ( 8 ) (yellow) and SARS-CoV-2 PL pro (PDB: 7CJM ). The blue area signifies the newly identified region in the binding pocket of SARS-CoV-2 PL pro .

    Journal: ACS Omega

    Article Title: SARS-CoV‑2 Papain-Like Protease Inhibitors Based on Naphthalen-1-ylethanamine and Halogenated Benzene Moieties

    doi: 10.1021/acsomega.5c05856

    Figure Lengend Snippet: Docking simulation of GRL-0048 ( 2 ) (orange) or KTS146 ( 8 ) (yellow) and SARS-CoV-2 PL pro (PDB: 7CJM ). The blue area signifies the newly identified region in the binding pocket of SARS-CoV-2 PL pro .

    Article Snippet: Briefly, the change in fluorescence intensity based on the cleavage of the fluorogenic substrate Z-Arg-Leu-Arg-Gly-Gly-4-methylcoumaryl-7-amide (AMC) (Sigma-Aldrich) caused by the SARS-CoV-1 PL pro (LifeSensors, Malvern, PA) or SARS-CoV-2 PL pro (MedChemExpress) was measured.

    Techniques: Binding Assay

    Structures of compounds ( 9a – y ), which target the hydrophilic amino acids of SARS-CoV-2 PL pro , with halogen substituents strategically positioned.

    Journal: ACS Omega

    Article Title: SARS-CoV‑2 Papain-Like Protease Inhibitors Based on Naphthalen-1-ylethanamine and Halogenated Benzene Moieties

    doi: 10.1021/acsomega.5c05856

    Figure Lengend Snippet: Structures of compounds ( 9a – y ), which target the hydrophilic amino acids of SARS-CoV-2 PL pro , with halogen substituents strategically positioned.

    Article Snippet: Briefly, the change in fluorescence intensity based on the cleavage of the fluorogenic substrate Z-Arg-Leu-Arg-Gly-Gly-4-methylcoumaryl-7-amide (AMC) (Sigma-Aldrich) caused by the SARS-CoV-1 PL pro (LifeSensors, Malvern, PA) or SARS-CoV-2 PL pro (MedChemExpress) was measured.

    Techniques:

    (left) 2D ligand interactions of compound 9c with SARS-CoV-2 PL pro (PDB: 7CJM ) by MOE. (right) Docking simulation of compound 9c (orange) with SARS-CoV-2 PL pro (PDB: 7CJM ). The docking protocol is based on a rigid receptor.

    Journal: ACS Omega

    Article Title: SARS-CoV‑2 Papain-Like Protease Inhibitors Based on Naphthalen-1-ylethanamine and Halogenated Benzene Moieties

    doi: 10.1021/acsomega.5c05856

    Figure Lengend Snippet: (left) 2D ligand interactions of compound 9c with SARS-CoV-2 PL pro (PDB: 7CJM ) by MOE. (right) Docking simulation of compound 9c (orange) with SARS-CoV-2 PL pro (PDB: 7CJM ). The docking protocol is based on a rigid receptor.

    Article Snippet: Briefly, the change in fluorescence intensity based on the cleavage of the fluorogenic substrate Z-Arg-Leu-Arg-Gly-Gly-4-methylcoumaryl-7-amide (AMC) (Sigma-Aldrich) caused by the SARS-CoV-1 PL pro (LifeSensors, Malvern, PA) or SARS-CoV-2 PL pro (MedChemExpress) was measured.

    Techniques:

    (left) 2D ligand interactions of compound 9m with SARS-CoV-2 PL pro (PDB: 7CJM ) by MOE. Docking simulation of compound 9m (orange) with SARS-CoV-2 PL pro (PDB: 7CJM ).

    Journal: ACS Omega

    Article Title: SARS-CoV‑2 Papain-Like Protease Inhibitors Based on Naphthalen-1-ylethanamine and Halogenated Benzene Moieties

    doi: 10.1021/acsomega.5c05856

    Figure Lengend Snippet: (left) 2D ligand interactions of compound 9m with SARS-CoV-2 PL pro (PDB: 7CJM ) by MOE. Docking simulation of compound 9m (orange) with SARS-CoV-2 PL pro (PDB: 7CJM ).

    Article Snippet: Briefly, the change in fluorescence intensity based on the cleavage of the fluorogenic substrate Z-Arg-Leu-Arg-Gly-Gly-4-methylcoumaryl-7-amide (AMC) (Sigma-Aldrich) caused by the SARS-CoV-1 PL pro (LifeSensors, Malvern, PA) or SARS-CoV-2 PL pro (MedChemExpress) was measured.

    Techniques:

    (left) 2D ligand interactions of compound 9r with SARS-CoV-2 PL pro (PDB: 7CJM ) by MOE. Docking simulation of compound 9r (orange) with SARS-CoV-2 PL pro (PDB: 7CJM ).

    Journal: ACS Omega

    Article Title: SARS-CoV‑2 Papain-Like Protease Inhibitors Based on Naphthalen-1-ylethanamine and Halogenated Benzene Moieties

    doi: 10.1021/acsomega.5c05856

    Figure Lengend Snippet: (left) 2D ligand interactions of compound 9r with SARS-CoV-2 PL pro (PDB: 7CJM ) by MOE. Docking simulation of compound 9r (orange) with SARS-CoV-2 PL pro (PDB: 7CJM ).

    Article Snippet: Briefly, the change in fluorescence intensity based on the cleavage of the fluorogenic substrate Z-Arg-Leu-Arg-Gly-Gly-4-methylcoumaryl-7-amide (AMC) (Sigma-Aldrich) caused by the SARS-CoV-1 PL pro (LifeSensors, Malvern, PA) or SARS-CoV-2 PL pro (MedChemExpress) was measured.

    Techniques:

    (left) 2D ligand interactions of compound 9v with SARS-CoV-2 PL pro (PDB: 7CJM ) by MOE. Docking simulation of compound 9v (orange) with SARS-CoV-2 PL pro (PDB: 7CJM ).

    Journal: ACS Omega

    Article Title: SARS-CoV‑2 Papain-Like Protease Inhibitors Based on Naphthalen-1-ylethanamine and Halogenated Benzene Moieties

    doi: 10.1021/acsomega.5c05856

    Figure Lengend Snippet: (left) 2D ligand interactions of compound 9v with SARS-CoV-2 PL pro (PDB: 7CJM ) by MOE. Docking simulation of compound 9v (orange) with SARS-CoV-2 PL pro (PDB: 7CJM ).

    Article Snippet: Briefly, the change in fluorescence intensity based on the cleavage of the fluorogenic substrate Z-Arg-Leu-Arg-Gly-Gly-4-methylcoumaryl-7-amide (AMC) (Sigma-Aldrich) caused by the SARS-CoV-1 PL pro (LifeSensors, Malvern, PA) or SARS-CoV-2 PL pro (MedChemExpress) was measured.

    Techniques: